ETHNIC SENSITIVITY ANALYSES OF PHARMACOKINETICS, EFFICACY AND SAFETY IN POLYCYTHEMIA VERA TREATMENT WITH ROPEGINTERFERON ALFA-2B

Ethnic sensitivity analyses of pharmacokinetics, efficacy and safety in polycythemia vera treatment with ropeginterferon alfa-2b

Ropeginterferon alfa-2b (Ropeg) is approved for the treatment of adults with polycythemia vera (PV).This report aims to analyze the ethnic sensitivity of Ropeg for the treatment of PV, comparing the pharmacokinetics (PK), efficacy, and safety profiles across diverse ethnic groups.We conducted a relevant review of PV and analysis of data obtained fr

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Steps in the bacterial flagellar motor.

The bacterial flagellar motor is a highly efficient rotary machine used by many bacteria to propel themselves.It has recently been shown that at low FINE GREY SEA SALT speeds its rotation proceeds in steps.Here we propose a simple physical model, based on the storage of energy in protein springs, that accounts for this stepping behavior as a random

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Development of a species-specific PCR assay for authentication of Agkistrodon acutus based on mitochondrial cytochrome b gene

Background: Agkistrodon acutus, a traditional Chinese medicine, clinically used in the treatment of rheumatism, tumor, and cardiovascular and cerebrovascular diseases.Due to the unique medicinal value and the difficulty of artificial breeding of Agkistrodon acutus, the supply of Agkistrodon acutus on the market exceeds the demand, and a large numbe

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Applying learning health systems thinking in codeveloping integrated tuberculosis interventions in the contexts of COVID-19

The COVID-19 pandemic reversed much of global progress made in combatting tuberculosis, with South Africa experiencing one of the largest impacts on tuberculosis detection.The aim of this Steering paper is to share our experiences in applying learning health systems (LHS) thinking to the codevelopment of an intervention improving an integrated resp

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